Prof. G. A. Clark, C.B.

Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors.

We have examined the ligand regulation and G protein selectivity of the human cannabinoid CB(1) and CB(2) receptors by an in situ reconstitution technique directly measuring G protein activation. Membranes from Spodoptera frugiperda cells expressing CB(1) and CB(2) receptors were chaotrope extracted to denature endogenous GTP-binding proteins. The ability of the receptors to catalyze the GDP-GT...

Prof. Dr. Prof. Prof.

A Letter for Honoring Prof. Takeshi Matsuura

Clark Glymour

Twenty years ago, Nancy Cartwright wrote a perceptive essay in which she clearly distinguished causal relations from associations, introduced philosophers to Simpson’s paradox, articulated the difficulties for reductive probabilistic analyses of causation that flow from these observations, and connected causal relations with strategies of action (Cartwright 1979). Five years later, without appr...

Katerina Clark